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MTHFR is a a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body's methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene's role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as 'mutations' or 'defects' because of the problems they cause in the body.

Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective.

Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body's ability to methylate or convert folic acid from the food we eat into Methylfolate.

Methylfolate is most often referred to as the 'active' or usable form of folate that our cells require. Because the body's cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it . It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.

The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered 'common' defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).

Everyone receives one copy of the MTHFR gene from each parent. This means a person could have any one of the following combinations as well as the issues that go with it:

Normal / Normal - Normal for the two common variants, or mutations, 677 and 1298 (no mutation is evident)

Normal / C677T - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

Normal / A1298C - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

A1298C / A1298C - Denoted as 1298CC - Much worse for the above problems (referred to as Homozygous)

C677T / C677T - Denoted as 677TT - Similar to 1298CC plus heart disease, blood clots, and more (referred to as Homozygous)

C677T / A1298C - Susceptible to all of the above and worse for strokes, heart disease, blood clots, etc. (referred to as Compound Heterozygous)


Nutritional Recommendations:



Methylation Complete Sublingual OR
Neuro-Immune Stabilizer Topical Cream

Homozygous for 1298 or C677 or combination: Provide Methylation Complete Sublingual or Neuro-Immune Stabilizer twice daily and add Methyl Folate Plus 1-2x’s daily (Niacinamide is an ingredient in the Methyl Folate Plus to support mitochondria and delivery of tetrahydrofolate)
Helpful Videos/ Audio:
5 minute Video: “Methylation For Patients with Kendal Stewart, MD” click on link:

Methylation Overview For Patients by Kendal Stewart, MD from Neurobiologix on Vimeo.


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Methyl B12 (methylcobalamin) 60 Lozenges (Retail $35.90) Methyl B12 (methylcobalamin) 60 Lozenges (Retail $35.90)

Active methylcobalamin form of vitamin B12. Provides 5,000 mcg (5 mg) of vitamin B12 as methylcobalamin, the active form especially useful for supporting neurological function and homocysteine metabolism.

These fast-dissolving tablets contain a high concentration of vitamin B12 to bypass normal absorptive mechanisms that rely on intrinsic factor. Studies show that B12 can be absorbed by passive diffusion across intestinal membranes when intake is greatly increased. Methyl-B12 Lozenge is a good choice for those with difficulty absorbing vitamin B12.

Tablets may be dissolved in the mouth or swallowed whole. Scored tablets contain natural cherry flavor and xylitol and mannitol as natural sweetening agents.


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Methyl Defend Complex 60 Capsules (Retail $37.50) Methyl Defend Complex 60 Capsules (Retail $37.50)

Supports normal homocysteine metabolism, detoxification, neurological function, and more.


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Methylation Pro Topical 120 Pumps (Retail $56.50) Methylation Pro Topical 120 Pumps (Retail $56.50)


Enhanced Formula With Additional 5-Methyltetrahydrofolate (5-MTHF) and Now Vitamin K For Improved Delivery

Advanced Topical Cream for Neurological, Nervous & Immune System Support / Ultimate Methylation Support

The addition of Vitamin K in this methylation suppport cream is recommended for those who are hindered by a methylation deficiency and/or a VDR Taq genetic polymorphism which inhibits the person's ability to absorb vitamin D at the cellular level without the cofactor Vitamin K. Impaired vitamin D function due to this polymorphism can result in significant immune weakness, early bone loss and increased risk of cognitive decline and mood issues.

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Neuro-Immune Stabilizer Creamª promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream may help maximize and aid in:

  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR Mutations
  • Short Term Memory Loss
  • Supporting a healthy sleep cycle
  • Immune Function and well-being
  • Patients with a VDR Taq mutation (SNP)
Such nutrients as Pyridoxal 5-Phosphate (B6) and Vitamin B12 in a methylated form called methylcobalamin (Methyl B12) and hydroxycobalamin (Hydroxy B12) and natural Vitamin D and K assist the body neurologically and physically.

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