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MTHFR Mutations
Now Available! Dr. Stewart's 5 segment workshop video series "Methylation, Mutations & Beyond the MTHFR".
View Now For Details:
https://vimeo.com/ondemand/drstewartseries2015/134...

MTHFR is a a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body's methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene's role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as 'mutations' or 'defects' because of the problems they cause in the body.

Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective.

Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body's ability to methylate or convert folic acid from the food we eat into Methylfolate.

Methylfolate is most often referred to as the 'active' or usable form of folate that our cells require. Because the body's cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it . It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.

The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered 'common' defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).

Everyone receives one copy of the MTHFR gene from each parent. This means a person could have any one of the following combinations as well as the issues that go with it:

Normal / Normal - Normal for the two common variants, or mutations, 677 and 1298 (no mutation is evident) 



Normal / C677T - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

Normal / A1298C - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

A1298C / A1298C - Denoted as 1298CC - Much worse for the above problems (referred to as Homozygous) 



C677T / C677T - Denoted as 677TT - Similar to 1298CC plus heart disease, blood clots, and more (referred to as Homozygous) 


C677T / A1298C - Susceptible to all of the above and worse for strokes, heart disease, blood clots, etc. (referred to as Compound Heterozygous)

Heterozygous A1298C or C677T or other symptoms of a methylation deficiency: Provide Methylation Complete Sublingual or Neuro-Immune Stabilizer twice daily and as directed on label.

Homozygous for 1298 or C677 or combination: Provide Methylation Complete Sublingual or Neuro-Immune Stabilizer twice daily and add Methyl Folate Plus 1-2x’s daily (Niacinamide it an ingredient in the Methyl Folate Plus to support mitochondria and delivery of tetrahydrofolate

Statement from Dr. Stewart: Many abnormalities (high folic acid in blood serum, low or high homocysteine, MTHFR mutation / heterozygous or homozygous) can point to a methylation deficiency. I find that many of my patients will respond better if you ease into the methylation protocol. Suggested use is begin with the Methylation Complete Sublingual OR Neuro-Immune Stabilizer Cream for about 2 weeks by itself and then add the Methyl Folate Plus if you feel it is necessary or with a homozygous result or heterozygous compound polymorphism result.

"Putting too much in too quickly can backfire on you symptomatically." Kendal Stewart, MD

Nutritional Recommendations: Nutrigenomic Key Coming Soon!
Helpful Videos/ Audio:
5 minute Video: “Methylation For Patients with Kendal Stewart, MD” click on link:

Methylation Overview For Patients by Kendal Stewart, MD from Neurobiologix on Vimeo.

Podcast on Coffee With Dr. Stewart Radio: Episode 13 On Genetic Testing,
Mutations and What They Mean
www.coffeewithdrstewart.podbean.com


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Methylation Complete Sublingual TRAVEL SIZE 10t (Retail $5.25) Methylation Complete Sublingual TRAVEL SIZE 10t (Retail $5.25)

TRAVEL SIZE OPTION - 10 tablets per bottle

2 Forms of Bioactive B12 (Methylcobalamin/Hydroxycobalamin) , B6 (P-5-P) and Methyl Folate
Ultimate Methylation Support and Dissolves In Under 60 Seconds!

Our unique sublingual delivery system assures that our pharmaceutical grade Methylation Complete™ promotes and enhances the methylation processes needed to improve the production of glutathione, and allow maximum B12, B6 and 5-Methyltetrahydrofolate delivery to the nervous and immune systems. This sublingual may help maximize and aid in:
  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR / MTRR Mutations
  • Short Term Memory
  • Cerebral Folate Deficiency
  • Hormonal Regulation
  • Sleep Patterns
  • Immune Function

Methylation Complete Sublingual Product Video with Dr. Kendal Stewart from Neurobiologix on Vimeo.


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Bioactive B12-Folate 60T / Retail $25.90 Bioactive B12-Folate 60T / Retail $25.90

High-potency, fast-dissolving tablets.

Bioactive B12-Folate® combines the active coenzyme form of vitamin B12, methylcobalamin, with an active form of folate, Metafolin®* L-5-methyltetrahydrofolate. This high-potency, bioactive formula was created to bypass normal absorptive mechanisms for vitamin B12 and folate which may be impaired due to aging, illness, gastrointestinal issues or a methylation deficiency.


Fast-dissolving and great tasting tablets allow for quick release into the bloodstream. Vitamin B12 and folate play an integral role in DNA synthesis and thus are essential to cell division and proper functioning of virtually all tissues in the body. Vitamin B12 and folate also participate in methylation and proper metabolism of homocysteine, a potentially toxic metabolite of methionine.

Dietary B12 can be reliably obtained only from animal products and is a singularly difficult vitamin to absorb. Bioactive B12-Folate may be especially beneficial for vegetarians and persons with impaired gastrointestinal absorptive function due to aging, illness, surgery or a methylation deficiency.


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Methyl B12 (methylcobalamin) 60 Lozenges (Retail $34.50) Methyl B12 (methylcobalamin) 60 Lozenges (Retail $34.50)

Active methylcobalamin form of vitamin B12. Provides 5,000 mcg (5 mg) of vitamin B12 as methylcobalamin, the active form especially useful for supporting neurological function and homocysteine metabolism.

These fast-dissolving tablets contain a high concentration of vitamin B12 to bypass normal absorptive mechanisms that rely on intrinsic factor. Studies show that B12 can be absorbed by passive diffusion across intestinal membranes when intake is greatly increased. Methyl-B12 Lozenge is a good choice for those with difficulty absorbing vitamin B12.

Tablets may be dissolved in the mouth or swallowed whole. Scored tablets contain natural cherry flavor and xylitol and mannitol as natural sweetening agents.


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Methyl Folate Plus Methyl Folate Plus - 90 Capsules (Retail $37.90)


Improved Formula Now With 30mg Vitamin B2 (Riboflavin-5-Phosphate)
and Niacinamide For Cofactor Delivery

This formula is an optimal methylation formula with activating co-factor created by Kendal Stewart, MD to support the methylation pathway and provide adequate folinic acid and methyl folate (5-MTHF).

This product is designed to be used in conjunction with the Methylation Complete Fast Dissolves OR Methylation Pro Topical that provides the activating B12 co-factors to deliver the additional tetrahydrofolate to support neurological and immune recovery. For those who have high folic acid levels in the blood plasma, then it can be assumed that folate is not being converted and entering the nervous sytem, immune system and blood brain barrier. Most often poor methylators will need additional folate.

The addition of Niacinamide helps support the mitochondria and supports as a cofactor for the delivery of the other ingredients in Methyl Folate Plus.

Dr. Stewart lecture: The Methyl Folate Deficiency.

The typical indications for this product include but are not limited to:

* Presence of Folate Receptor Autoantibodies

*Homozygous (2 copies) MTHFR polymorphism

*Increased requirement for development (age 8-20)

*Acute recovery from major neurological injuries

*Moderate to severe autism related issues

*Poor recovery from surgery or injury


Dr. Stewart Discusses Methyl Folate Plus and It's Use for Neuro-Immune Syndromes from Neurobiologix on Vimeo.


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Full Focus+ 120C (Retail $43.90) Full Focus+ 120C (Retail $43.90)

Exclusive formula created by leading Neuro-Immune/Genomic Specialist, Kendal Stewart, M.D., that is safe and effective for patients of all ages. This product was designed and may assist with:

*Attention and Concentration Levels
*Boost Cognition and Motor Activity Skills
*Improve Visual Speed and Accuracy
*Improve Dopamine Turnover
*Improve Learning and Organization
*Support Methylation Process
*Improve Brain Performance
*Stabilize Behavior and Mood


Full Focus+™ consists of 12 ingredients carefully formulated by our advising physicians to work together to maximize each ingredients's full potential and improve vitamin delivery. This processing support formula consists of very important ingredients such as Green Coffee Bean extract, SAMe, L-Taurine, L-Methionine and other important ingredients for cognitive and cellular performance.

The Full Focus+ formula is specifically crafted to nutritionally assist in restoring normal dopamine production and improving the functionality of dopamine processing.

Download product information card: http://www.neurobiologix.com/v/vspfiles/downloadables/RackCard-FullFocus_Neuro_web.pdf


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Methyl Defend Complex 60 Capsules (Retail $35.90) Methyl Defend Complex 60 Capsules (Retail $35.90)

Supports normal homocysteine metabolism, detoxification, neurological function, and more.


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Nrf2/SOD Enhancer (NOW CALLED N.A.S. Enhancer) 60C Nrf2/SOD Enhancer (NOW CALLED N.A.S. Enhancer) 60C

This product has had a name change to N.A.S. Enhancer and now features additional ingredients for formula enhancement.


Click Here To Order:
http://www.neurobiologix.com/NAS-Enhancer-p/302.ht...

Nrf2/SOD Enhancer, NOW CALLED
N.A.S. Enhancer is a combination of well studied nutritional ingredients that are known to activate the basic leucine zipper protein in the NRF2 genetic pathway. It is designed to increase the cellular production of antioxidant proteins. This important pathway regulates the production of antioxidant enzymes such as catalase, Glutathione and Superoxide Dismutase (SOD). These antioxidant enzymes are powertul enough to neutralize up to one million free radicals per second.This one to one million ratio has been shown to be a far more effective approach in combating aging.*

This product is designed to assist those with:


  • Antioxidant Support Need*
  • High Inflammatory Responses*
  • Genetic Weakness (SNPs) in the GSTP, GSTM, SOD2 or SOD3 Genes*, ATG16L1
  • Detoxification Pathway Issues*
  • Methylation Deficiencies*

N.A.S. Enhancer Product Video from Neurobiologix on Vimeo.


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Methylation Complete Sublingual 120T (Retail $53.90) Methylation Complete Sublingual 120T (Retail $53.90)


2 Forms of Bioactive B12 (Methylcobalamin / Hydroxycobalamin) , B6 (P-5-P) and Methyl Folate (5-Methyltetrahydrofolate)
Ultimate Methylation Support and Dissolves In Under 60 Seconds!

Our unique sublingual delivery system assures that our pharmaceutical grade Methylation Complete™ promotes and enhances the methylation processes needed to improve the production of glutathione, and allow maximum B12, B6 and 5-Methyltetrahydrofolate delivery to the nervous and immune systems. This sublingual may help maximize and aid in:
  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR / MTRR Mutations
  • Short Term Memory
  • Cerebral Folate Deficiency
  • Hormonal Regulation
  • Sleep Patterns
  • Immune Function

Methylation Complete Sublingual Product Video with Dr. Kendal Stewart from Neurobiologix on Vimeo.


Our Price: (Members Only)
Glutathione Plus Topical - (Retail $56.00) Glutathione Plus Topical - (Retail $56.00)

For other glutathione formulas CLICK HERE

50 mg of L-Glutathione Per Pump!
Enhancing the Immune System - Your bodies immune activity, involving unimpeded multiplication of lymphocytes and antibody production,
requires maintenance of normal levels of glutathione inside the lymphocytes.

Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses,
pollutants and free radicals.

Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job
adequately to protect your body against disease.

A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as
carcinogens and harmful metabolites.


As a solution, our unique liposome-mediated delivery system, is a glutathione cream with supporting raw materials and co-factors
involved in the methylation process needed to enhance the efficacy of the glutathione.

…Especially of heavy metals. Glutathione is a tripeptide found in all of our cells. In good health, glutathione levels are high;
in every condition of poor health glutathione levels are low. As homocysteine is broken down in the methylation process, glutathione levels increase. Glutathione is the master antioxidant (scavenging free radicals), master anti-inflammatory, and master detoxifier.
It is especially potent in detoxifying heavy metals such as mercury, aluminum, lead, and cadmium. It also pulls out PCBs and synthetic estrogens. Further, when cells are rich in glutathione, it is more difficult to intoxicate them in the first place.


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Methylation Pro Topical 2oz. (Retail $55.90) NEW! Methylation Pro Topical 2oz. (Retail $55.90) NEW!

NEW!
Enhanced Formula With Additional 5-Methyltetrahydrofolate (5-MTHF) and Now Vitamin K For Improved Delivery

Advanced Topical Cream for Neurological, Nervous & Immune System Support / Ultimate Methylation Support

The addition of Vitamin K in this methylation suppport cream is recommended for those who are hindered by a methylation deficiency and/or a VDR Taq genetic polymorphism which inhibits the person's ability to absorb vitamin D at the cellular level without the cofactor Vitamin K. Impaired vitamin D function due to this polymorphism can result in significant immune weakness, early bone loss and increased risk of cognitive decline and mood issues.

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Neuro-Immune Stabilizer Creamª promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream may help maximize and aid in:

  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR Mutations
  • Short Term Memory Loss
  • Supporting a healthy sleep cycle
  • Immune Function and well-being
  • Patients with a VDR Taq mutation (SNP)
Such nutrients as Pyridoxal 5-Phosphate (B6) and Vitamin B12 in a methylated form called methylcobalamin (Methyl B12) and hydroxycobalamin (Hydroxy B12) and natural Vitamin D and K assist the body neurologically and physically.

To download this product card click
HERE


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neuro methylation cream Neuro-Immune Stabilizer Topical Cream (120 pumps) / (Retail $55.90)

Now Available! Enhanced Formula With Additional 5-Methyltetrahydrofolate (5-MTHF) and Improved Delivery System!
Topical Cream for Neurological, Nervous & Immune System Support

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Neuro-Immune Stabilizer Cream promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream can help maximize and aid in:
  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • 5 MTHR Mutation
  • Short Term Memory Loss
  • Cerebral Folate Deficiency
  • Hormonal Regulation
  • Sleep Patterns
  • Immune Function
Active Ingredients: 5-Methyltetrahydrofolate (5-MTHF), Methyl B12, Hydroxy B12, Pyridoxal 5-Phosphate (B6) and 1,000 IU's Vitamin D per pump.



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